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Formulation and Evaluation of Sunscreen Spray Gel Enriched with Potent Lime Peel Extract for Superior Natural UV Protection and Skin Care

Authors:

Mukesh barman¹,Gourishankar birtia^1*,Tilotma Sahu²

Rungta Institute of Pharmaceutical Sciences, Bhilai , Durg Chhattisgarh, India¹

Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari , Durg , Chhattisgarh , India²

Email :  birtiagouri@rediffmail.com

Abstract:

The present study focuses on the formulation and evaluation of a lime peel extract-based spray gel for its antioxidant and transdermal delivery potential. The gel was formulated using Carbopol 940, HPMC, and propylene glycol to ensure optimal consistency and stability. The antioxidant potential was assessed using the DPPH free-radical scavenging assay, while in vitro drug release and skin permeation studies were conducted to evaluate transdermal diffusion.

The DPPH assay results demonstrated concentration-dependent free radical scavenging activity, with F3 (15% lime peel extract) exhibiting the highest antioxidant potential (~92% inhibition at 500 µg/mL). The drug content ranged from 95.2% to 98.8%, confirming efficient incorporation of the active ingredient. In vitro permeation studies indicated a direct correlation between extract concentration and diffusion rate, with F3 showing maximum permeation (100 µg/cm²) over 22 hours. The release profile followed a sustained diffusion-controlled mechanism, highlighting the potential for prolonged antioxidant activity.

The findings suggest that lime peel extract-based spray gel offers significant antioxidant properties, making it a promising candidate for topical applications in skincare, particularly for anti-aging and skin-protective formulations. Further optimization may enhance its therapeutic efficacy and stability.