Stimuli-Responsive Supramolecular Hydrogels in Precision Medicine: Recent Advances, Challenges, and Translational Perspectives

Authors:

Author Name (Shreyansh Chaturvedi phd scholar, Dr Arti Malviya Research supervisor)
Affiliation: LNCT University
Emailshreyansh02chaturvedi@gmail.com

Abstract. An appealing form of dynamic biomaterial that has emerged as a potential in future biomedical applications is supramolecular hydrogels which can be stimulated or respond to currents. The hydrogels are formed through reversible non-covalent interactions which are capable of adapting them to response to therapeutically significant stimuli. This reactivity allows the drugs to be discharged in a controlled manner thereby rendering the drugs highly useful in tissue engineering, targeted drug delivery and cancer treatment. Their functionality and application in precision medicine have also been enhanced by new advancement of molecular design, hybrid nanocomposites and multifunctional systems. Nevertheless, there are a number of issues remaining such as the structural stability limitation, the biocompatibility, the problems in mass production and complicated regulations. These are critical issues that need to be addressed to enable successful clinical translation. Regardless of them, the intelligent response of these hydrogels to biological signals and delivery of customized therapeutic results highlight substantial significance in the next-generation healthcare. They have significant chances to be integrated into the precision medicine systems and enhance the efficiency of treatments, minimize the side effects, and offer more tailored treatment methods to the patients.

Index Terms: Target medicine, stimuli responsive hydrogels, supramolecular chemistry, targeted drug delivery.