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A Review on

GASTRO-RETENTIVE DRUG DELIVERY SYSTEM

Sadanand Chauhan, Pooja Chauhan, Pratima Chauhan, Shweta Mishra, Jitendra Jena

^1,2,3, Research Scholar, Pharmacy College, Itaura, Chandeshwar, Azamgarh, U.P. India.

³Assistant Professor, Pharmacy College, Itaura, Chandeshwar, Azamgarh, U.P. India.

⁴Associate Professor, Pharmacy College, Itaura, Chandeshwar, Azamgarh, U.P. India

Corresponding Author: sadanandchauhan321@gmail.com

Abstract

The aim of this review is to focus on the various gastro retentive approaches by investigate, compile, and present in most concise way, where the gastroprotective has gained immense popularity in the field of oral drug delivery.  In the field of oral drug delivery gastro-retentive drug delivery play an important role. There are various types of GRDDS approaches which can be utilized to retain the dosage form in the stomach and release the drug slowly for an extended period of time. The various GRDDS approaches include high density, low density, mucoadhesive, expandable, magnetic systems and super porous hydrogel system. GRDDS has proved to be effective in both local and systemic actions to treat gastric or duodenal ulcers. Gastro-retentive drug delivery system can be utilized to prolong the residence time of delivery system in the stomach. Where the stomach and duodenum are separated by the pylorus, which has an important role in residence time of the ingested substances in the stomach. GRDDS can be used to overcome challenges related with conventional oral dosage forms.

Keywords

Gastro-retentive, GRDDS, Oral route, GIT, various approaches, floating system, non-floating system, bio adhesive system.