International Scientific Journal of Engineering and Management

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FORMULATION AND EVALUATION OF OINTMENT CONTAINING CRISABOROLE

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FORMULATION AND EVALUATION OF OINTMENT CONTAINING CRISABOROLE

Shubham Vijay Patel*, Gaurav Jain and Rakesh Patel

Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Indore (M.P.) - India

 

Abstract

Crisaborole has broad-spectrum anti-inflammatory activity by mainly targeting phosphodiesterase 4 (PDE4) enzyme that is a key regulator of inflammatory cytokine production. As this enzyme is expressed in keratinocytes and immune cells, crisaborole mediates an anti-inflammatory effect on almost all inflammatory cells. Topical application of this drug is useful as it potentiates the localization of this drug in the skin and this anti-inflammatory activity is in the low micromolar range.  The objective of present research work is to enhance the aqueous solubility of poorly water soluble drug Crisaborole using Co-solvency technique. The prepared formulation was evaluated for physical characteristics, drug content and drug release.

 

Keywords: Crisaborole, Ointment, Co-solvency


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