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The Synthesis, Isolated and Characterization Conjugated Linoleic Acid(CLA) from Datura Innoxia Mill Seed

Dr.Veerendra S. Yadav, Dr.Sanjay Gaikwad, Dr.Devidas Patil, Mr. Dinesh Gaikwad,
Department of Chemistry: BJS ASC College Wagholi Pune
Department of Botany: BJS ASC College Wagholi Pune

ABSTRACT
The identification of conjugated linoleic acid (CLA) in Datura species represents a novel and promising avenue for
biomedical exploration. CLA comprises a group of positional and geometric isomers of linoleic acid, renowned for their
wide-ranging health benefits, including anti-obesity, anti-diabetogenic, and anti-carcinogenic properties. While CLA is
conventionally obtained from ruminant-derived dairy and meat products, the discovery of its potential occurrence in
Datura offers a compelling plant-based alternative source. Preclinical studies have established CLA’s ability to inhibit
tumorigenesis via multiple mechanisms, including the induction of apoptosis, suppression of cell proliferation,
modulation of immune responses, and inhibition of angiogenesis. However, clinical trials in human subjects have yielded
inconsistent outcomes, highlighting the need for continued investigation into its efficacy and therapeutic scope. Building
upon these insights, the present study aims to extract, purify, and characterize CLA from Datura seeds, followed by
evaluation of its anticancer potential. This will involve in vitro cytotoxicity assays against human cancer cell lines and
mechanistic studies to elucidate its molecular mode of action. The overarching goal is to develop a CLA-based natural
formulation with potential application as an anticancer therapeutic agent
KEY WORD: Datura Innoxia Mill, CLA, Reflex reaction, Magnetic steroid,