Synergistic Effects of Tridax procumbens and Tagetes erecta in a Biodegradable Wound Healing Bandage
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Synergistic Effects of Tridax procumbens and Tagetes erecta in a Biodegradable Wound Healing Bandage
Authors:
Dr.M.Kaviyalakshmi1*, Ms. Angelin Viji2, Ms. D. Nivethini3
1Department of Bioscience, Sri Krishna Arts and Science College
2Department of Bioscience, Sri Krishna Arts and Science College
3Department of Microbiology, Sri Ramakrishna College of Arts and Science for Women
Abstract - In the pursuit of sustainable and bioactive alternatives to conventional wound care, this study presents the development and evaluation of a novel herbal bandage infused with ethanol extracts of Tridax procumbens and Tagetes erecta. Addressing the limitations of synthetic dressings—such as poor biocompatibility, lack of therapeutic action, and environmental impact—this project integrates traditional medicinal plants into a modern wound-healing matrix. A 2:1 extract ratio was optimized based on antimicrobial efficacy against Escherichia coli, Staphylococcus aureus, and Candida spp. Phytochemical analysis confirmed the presence of flavonoids, tannins, glycosides, phenols, and terpenoids, contributing to the extract's multifaceted biological activity. FTIR spectroscopy further validated the biochemical functionality through the identification of phenolic, alcoholic, carbonyl, and ester groups. The formulated bandage demonstrated significant antioxidant activity (85.44% DPPH radical scavenging at 100 µg/mL) and anti-inflammatory potential (80.8% inhibition of protein denaturation at 50 µg/mL). In vitro antimicrobial tests revealed superior zones of inhibition in extract-coated fabrics, particularly in the 2:1 combination. Physiological assessments indicated no skin irritation or allergic reactions, supporting its dermatological safety. The bandage exhibited uniform spreadability, ideal pH (6), and favorable physical characteristics. This work highlights the synergistic potential of plant-based biomedical textiles as eco-friendly, biocompatible, and therapeutically active wound dressings, combining traditional knowledge with modern biomedical innovations. Further studies may explore scale-up and clinical applicability.
Key Words: Tridax procumbens, Tagetes erecta, Wound healing, antimicrobial, synergistic.